Gilbert Melendez will take on Diego Sanchez in his second UFC outing, as the promotion has confirmed that the two lightweights will battle October 19th at UFC 166. The UFC has also announced that as as expected, UFC 166 will feature heavyweight champ Cain Velasquez taking on Junior dos Santos, and Hector Lombard fighting Nate Marquardt. That’s three pretty big fights.

Melendez (21-3) will be fighting for the first time since he threw down with lightweight champ Benson Henderson at UFC on FOX 7, and lost by split decision. The loss marked the first time Melendez had lost in seven fights and since 2008. During that time Melendez continued to entrench his position as a top ranked lightweight, by defeating tough vets like Shinya Aoki, Jorge Masvidal and Josh Thomson.

Sanchez (24-5) is coming off narrow, split decision win over former PRIDE star Takanori Gomi at UFC on FUEL TV 8 in March, after dropping a unanimous decision loss to welterweight contender Jake Ellenberger last February. Sanchez elected to return to lightweight after facing Ellenberger, which left his record at 2-2 in his most recent run at 170 pounds.

Considering Melendez is the #1 contender in the UFC lightweight division, Sanchez, who isn’t in the top ten, could make a huge statement by defeating the former Strikeforce champ.

UFC 166 will be hosted by Houston’s Toyota Center and the main card will be broadcast via pay-per-view.

Stay tuned to Caged for all your UFC 166 coverage.