Gilbert Melendez will take on Diego Sanchez in his second UFC outing, as the promotion has confirmed that the two lightweights will battle October 19th at UFC 166. The UFC has also announced that as as expected, UFC 166 will feature heavyweight champ Cain Velasquez taking on Junior dos Santos, and Hector Lombard fighting Nate Marquardt. That’s three pretty big fights.

Melendez (21-3) will be fighting for the first time since he threw down with lightweight champ Benson Henderson at UFC on FOX 7, and lost by split decision. The loss marked the first time Melendez had lost in seven fights and since 2008. During that time Melendez continued to entrench his position as a top ranked lightweight, by defeating tough vets like Shinya Aoki, Jorge Masvidal and Josh Thomson.

Sanchez (24-5) is coming off narrow, split decision win over former PRIDE star Takanori Gomi at UFC on FUEL TV 8 in March, after dropping a unanimous decision loss to welterweight contender Jake Ellenberger last February. Sanchez elected to return to lightweight after facing Ellenberger, which left his record at 2-2 in his most recent run at 170 pounds.

Considering Melendez is the #1 contender in the UFC lightweight division, Sanchez, who isn’t in the top ten, could make a huge statement by defeating the former Strikeforce champ.

UFC 166 will be hosted by Houston’s Toyota Center and the main card will be broadcast via pay-per-view.

Stay tuned to Caged Insider.com for all your UFC 166 coverage.

Gilbert wins easily!

This will be such a great fight“@CagedInsider: UFC 166: Gilbert Melendez-Diego Sanchez Confirmed — http://t.co/FInPToAgqz”

RT @CagedInsider: UFC 166: Gilbert Melendez-Diego Sanchez Confirmed — http://t.co/2BKXaJMTAY

SIC FIGHT “@CagedInsider: UFC 166: Gilbert Melendez-Diego Sanchez Confirmed — http://t.co/aEaTy2aMQF“

super dumb match up…bj penn/nurmagomedov is a better match up

UFC 166: Gilbert Melendez-Diego Sanchez Confirmed http://t.co/iB0bCwamFc

It’s gunna b WAR mfs!

RT @CagedInsider: UFC 166: Gilbert Melendez-Diego Sanchez Confirmed http://t.co/iB0bCwamFc

Melendez is gonna be a nightmare for sanchez…lol

He is like Sanchez 2.0, more refined everywhere.

RT @CagedInsider: UFC 166: Gilbert Melendez-Diego Sanchez Confirmed http://t.co/iB0bCwamFc

Cain vs Junior III, Lombard vs Marquardt, now this, getting stacked nicely.

RT @CagedInsider: UFC 166: Gilbert Melendez-Diego Sanchez Confirmed http://t.co/iB0bCwamFc

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I can’t believe some people are counting out Diego. Diego is a beast but it all depends on who shows up to fight.

fk yeah..thats the fight I’d liike to see

RT @CagedInsider: UFC 166: Gilbert Melendez-Diego Sanchez Confirmed — http://t.co/2BKXaJMTAY

Sanchez all the way

He should be the nightmare and put tap him out

@CagedInsider why is this fight happening?

melendez all the way,

Sanchez, he is gonna make Melendez dream

RT @CagedInsider: UFC 166: Gilbert Melendez-Diego Sanchez Confirmed http://t.co/iB0bCwamFc

RT @CagedInsider: UFC 166: Gilbert Melendez-Diego Sanchez Confirmed — http://t.co/2BKXaJMTAY

can’t wait for this match.

Fight of the Night. If they come to destroy each other.

Sanchez ain’t even match for my boy gil…….he won against benson…..the judges are blind…..but I’m glad he’s fighting……

Woo this one is going to be good! Going to enjoy watching this one!

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RT @CagedInsider: UFC 166: Gilbert Melendez-Diego Sanchez Confirmed http://t.co/iB0bCwamFc

Diego got this,great fight cnt wait.

gilbert is in my mind the ufc lightweight champ

Sanchez!? Really – Thats awesome Gil – Easy win.

RT @CagedInsider: UFC 166: Gilbert Melendez-Diego Sanchez Confirmed http://t.co/iB0bCwamFc

Sanchez all the way if he shows up to bang hes takin the fight!!!

Not A Melendez Fan, But he is a more skilled figher than Sanchez, and will Beat ‘Diego’ down!! Should be good one anyways, can’t wait to see !!

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